Dysfunctional Postnatal Mitochondrial Energy Metabolism in a Patient with Neurodevelopmental Defects Caused by Intrauterine Growth Restriction Due to Idiopathic Placental Insufficiency
Abstract
:1. Introduction
2. Results
2.1. Clinical History
2.2. Functional Studies of the ATP Metabolism
2.3. Mitochondrial Morphometric Examination of the Proband’s Fibroblasts
3. Discussion
4. Materials and Methods
4.1. Editorial Policies and Ethical Considerations
4.2. Skin Biopsy and Fibroblast Culture
4.3. Clinical Genetic Diagnosis
4.4. Transmission Electron Microscopy
4.5. Live-Cell Measurements of Mitochondrial Respiratory and Glycolytic Activity
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Uittenbogaard, M.; Gropman, A.L.; Whitehead, M.T.; Brantner, C.A.; Gropman, E.; Chiaramello, A. Dysfunctional Postnatal Mitochondrial Energy Metabolism in a Patient with Neurodevelopmental Defects Caused by Intrauterine Growth Restriction Due to Idiopathic Placental Insufficiency. Int. J. Mol. Sci. 2024, 25, 1386. https://doi.org/10.3390/ijms25031386
Uittenbogaard M, Gropman AL, Whitehead MT, Brantner CA, Gropman E, Chiaramello A. Dysfunctional Postnatal Mitochondrial Energy Metabolism in a Patient with Neurodevelopmental Defects Caused by Intrauterine Growth Restriction Due to Idiopathic Placental Insufficiency. International Journal of Molecular Sciences. 2024; 25(3):1386. https://doi.org/10.3390/ijms25031386
Chicago/Turabian StyleUittenbogaard, Martine, Andrea L. Gropman, Matthew T. Whitehead, Christine A. Brantner, Eliana Gropman, and Anne Chiaramello. 2024. "Dysfunctional Postnatal Mitochondrial Energy Metabolism in a Patient with Neurodevelopmental Defects Caused by Intrauterine Growth Restriction Due to Idiopathic Placental Insufficiency" International Journal of Molecular Sciences 25, no. 3: 1386. https://doi.org/10.3390/ijms25031386